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Mol Psychiatry 30 , 60206032 (2025)

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However, it is important to note that data on mortality rates related to chronic liver diseases, such as cirrhosis, may be conservative, and research studies may not fully capture the true extent of the global burden (Asrani et al., 2013)

In this review, we will discuss the spread of cancer cells through the lymphatic system, the roles of TDLNs in metastasis and anti-cancer immune responses, and the therapeutic opportunities and challenges in targeting LN metastasis